Up All Night is tearing at the seams. After NBC pulled the show from it schedule in December, it decided to change the single-cam sitcom to multi-cam with a live audience and all and amidst the news of such a drastic revamp series creator Emily Spivey departed the show and original showrunner Jon Pollack stepped away as did his successor Tucker Cawley. And now, series star Christina Applegate is leaving.

“It’s been a great experience working on Up All Night, but the show has taken a different creative direction and I decided it was best for me to move on to other endeavors,” said Applegate. “Working with [executive producer] Lorne Michaels has been a dream come true and I am grateful he brought me into his TV family. I will miss the cast, producers and crew, and wish them the best always.”

Like Spivey before her, Applegate could not accept the massive creative changes happening at the show and so she bid it adieu. So what exactly does this mean for the show? NBC has yet to comment on the news, but according to Deadline the show is not dead yet and they’re looking at replacing Applegate’s with a new actress, possibly Lisa Kudrow of Friends fame.

NBC ordered five more episodes to round out Up All Night‘s second season. With an Applegate replaced it can technically live on to test its multi-cam experiment this spring. When the show’s overhaul was announced I was a bit skeptical about its future; now with Applegate out I don’t see it having one.

Update (2/12): According to Deadline, NBC has reduced the multi-cam episode order from 5 to 1 and the network is still interested in testing new waters even without the show’s star Christina Applegate. James Burrows is set to direct the episode.

[Via Deadline]